文章摘要
胡咏新,孙利,褚晓秋,谢绍锋,刘超.左归丸对甲强龙脉冲治疗Graves眼病骨代谢水平的影响[J].南京中医药大学学报(自然科学版),2017,33(2):118-121.
左归丸对甲强龙脉冲治疗Graves眼病骨代谢水平的影响
Influence of Zuogui Pill on Bone Metabolism in Grave's Ophthalmopathy After Methylprednisolone Pulse Therapy
投稿时间:2016-10-02  修订日期:2016-12-10
DOI:
中文关键词: Graves眼病  左归丸  脉冲治疗  骨标记物
英文关键词: Grave's ophthalmopathy  Zuogui Pill  methylprednisolone pulse therapy  bone biomarker
基金项目:
作者单位
胡咏新,孙利,褚晓秋,谢绍锋,刘超* 南京中医药大学附属中西医结合医院江苏 南京 ;210028 
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中文摘要:
      目的 探讨经方左归丸对甲强龙脉冲治疗Graves眼病(GO)骨代谢指标:1型前胶原N-端前肽(P1NP)、β-1型胶原羧基端肽(β-CTX)、25羟维生素D(25OHD)和碱性磷酸酶(ALP)的影响。方法 选取符合条件的GO肾阴亏虚患者60例,其中治疗组32例,对照组28例,治疗组给予脉冲治疗联合左归丸,对照组给予脉冲治疗联合安慰剂,观察治疗前后2组证候积分、骨生化标记物的变化。结果 治疗组治疗后证候评分较前明显好转(P<0.05),其中腰膝酸软、潮热盗汗改善明显优于对照组(P<0.05),疗效优于对照组(P<0.01)。血β-CTX、ALP水平明显降低,其中β-CTX水平与对照组比有显著性差异(P<0.05)。2组治疗后CAS积分、充血、水肿、疼痛症状都有明显改善(P<0.01),但组间比,P>0.05。结论 中药左归丸可以改善肾阴虚证候,抑制破骨细胞活性,纠正高骨转换,对预防糖皮质激素导致的骨质疏松有一定疗效。
英文摘要:
      OBJECTIVE To explore the influences of Zuogui Pill on such bone metabolism indexes as P1NP, β-CTX, 25OHD and ALP in patients with Grave's ophthalmopathy(GO) after methylprednisolone pulse therapy. METHODS 60 cases with GO due to kidney yin deficiency catering for the condition were selected and into the treatment group(32 cases) and the control group(28 cases). Patients in the treatment group were given methylprednisolone pulse therapy and Zuogui Pill, while those in the control group were treated with methylprednisolone pulse therapy and placebo. The syndrome integral scores and bone biochemical markers of both groups were observed before and after treatment. RESULTS The syndrome integral scores of the treatment group experienced an evident improvement than before(P<0.05). The treatment group is more superior to the control group in improving soreness and weakness of waist and knees, tidal fever and night sweating(P<0.05), with better therapeutic effects(P<0.01). Both β-CTX and ALP levels in the blood serum went down, with significant differences being noticed in the β-CTX level of both treatment groups(P<0.05). CONCLUSION Chinese medicine Zuogui Pill is able to improve the symptoms caused by kidney yin deficiency, inhibit the osteoclast activity, rectify the high-bone turnover, which is conductive to preventing osteoporosis due to glucocorticoid.
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